Comparison of Diagnostic Accuracy of Anti-mullerian Hormone with Follicle Stimulating Hormone for Ovarian Reserve Assessment in Infertile Women by Roc Analysis
نویسنده
چکیده
OBJECTIVE: To compare the diagnostic accuracy of Anti-Mullerian hormone with follicle stimulating hormone for ovarian reserve assessment in infertile women by Receiver Operator Characteristic curve analysis. STUDY DESIGN: A Cross Sectional study. PLACE AND DURATION OF STUDY: At Institute of Basic Medical Sciences, University of Health Sciences in collaboration with nd th Gynecology and Obstetrics Unit-II, Civil Hospital, Karachi from 2 October 2011 to 15 October 2012. METHODOLOGY: Fifty two infertile women between 20-35 years of age were selected from the out-patient. Out of 52 females, 25 women presented with primary infertility (no history of previous pregnancy) and 27 were secondary sub-fertile (history of previous pregnancy). Blood samples were obtained for follicle stimulating hormone and Anti-mullerian hormone levels. RESULTS: Descriptive statistics for Anti-mullerian hormone and follicle stimulating hormone levels was taken as mean ± SD (26 ±4.02, 1.6± 0.62 and 8.98± 0.701) respectively. The sensitivity, specificity and accuracy of serum Anti-mullerian hormone levels and follicle stimulating hormone were evaluated by receiver operating characteristic curve (ROC curve). Area under the curve was 0.80 (AUC: 0.92) with standard error of 0.044 which was significant (P<0.05). Sensitivity and specificity was 79% and 88% respectively. Area under the curve for follicle stimulating hormone was 0.70 (AUC: 0.70) which was significant (P<0.05). Sensitivity and specificity was 65% and 76% respectively. CONCLUSION: Anti-mullerian hormone assay has shown greater sensitivity so Anti-mullerian hormone assay can be used as a reliable diagnostic test for ovarian reserve assessment in infertile women.
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